UNICs work in partnership with members of civil society who are actively involved with issues of concern to the United Nations. Non-governmental organizations (NGOs) count on UNICs as partners in organizing seminars, exhibits and commemorative events, focusing on such key issues as the promotion of human rights, the protection of the environment, disease control and the prevention of drug abuse/trafficking. Staffed with communications professionals who understand the concerns of their local communities, UNICs are often catalysts that bring people together to address the world's toughest challenges.

Non-governmental organizations have worked with the Department of Global Communications since 1946 and are indispensable partners for UN efforts at the country level. There are currently over 1,600 NGOs associated with DPI.